Our Latest Published Research

Efficacy and Safety of Low Level Electromagnetic Fields Treatment in Parkinson’s Disease.

O. Klepitskaya, R. Kumar, University of Colorado Health Sciences Center, Department of Neurology, Aurora, CO, USA; Colorado Neurological Institute Movement Disorder Center, Englewood, CO, USA.

Background:

Small case series suggest extremely low level (10212Tesla) electromagnetic fields (EMF) may be useful in the treatment of Parkinson’s disease (PD). No controlled studies have been previously reported.

Design/Methods:

A single center, double blind, randomized, placebo controlled trial of EMF as an adjuvant to standard medical therapy in PD patients with motor fluctuations was performed in 12 subjects (6 per group). 24 sessions of 1.5 hour of total body EMF were administered over 8 weeks. Standardized motor and non-motor assessments were performed prior to treatment, at endpoint, and monthly for 3 months.

Results:

The treatment group demonstrated significant improvement over placebo after 8 weeks of therapy as follows: Scale, absolute point reduction, % improvement vs % improvement placebo (unless noted all results p.05): UPDRS II(ON) 5.5, 56% vs 28%; UPDRS III(ON) 9.5, 40% vs 20%, p5.054; PDQ-39(SI) 8.4, 42% vs 7%; PDQ-39(MOB) 11.67, 47% vs 6%; PDQ-39(ADL) 15.97 pts, 64% vs 9%; PDQ-39(BD) 8.33 pts, 30% vs -13%; Beck Depression Inventory II 5.73 pts, 47% vs 1%; Fatigue Severity Scale 7.66 pts, 22% vs 5%, p5.12; Finger Taps (ON) 67 taps, 25% vs -5%. Importantly, improvement on several scales persisted up to 2 months post treatment. No treatment related adverse events reported.

Conclusions:

Low level EMF may improve motor and non-motor features of PD beyond that achieved with standard medical therapy. These effects are long-lasting. Larger placebo-controlled studies should be undertaken to confirm and further investigate the benefit of this unique, noninvasive and potentially promising therapy.


Research published in the Heart Rhythm Society journal Heart Rhythm O2 concluded: "In this first-in-human, proof-of-concept study in patients with paroxysmal AF, LL-EMF stimulation results in significantly shorter episodes of pacing-induced AF, as well as a reduced likelihood of spontaneous firing initiating an episode of AF, compared to sham stimulation. Larger studies are warranted to confirm these findings and provide further mechanistic insights."

Key Findings

  • Low-level electromagnetic field stimulation (LL-EMF) is able to suppress the inducibility of atrial fibrillation (AF) in patients presenting for ablation of paroxysmal AF.
  • LL-EMF decreased levels of monocyte chemoattractant protein-1 measured in peripheral venous blood.
  • LL-EMF represents an interesting new approach for noninvasive management of AF, and requires further study to assess its efficacy in improving clinical AF outcomes.


In addition, we have over 25 years of scientific research and clinical studies involving both animals and humans which have been conducted using our technology by leading scientists and medical researchers at the following institutions:

  • Colorado Neurological Institute, USA
  • Fairleigh Dickinson University, NJ, USA
  • University of South Florida's Institutional Review Board, USA
  • Independent Review Consulting, CA, USA
  • University of Oklahoma Heart Rhythm Institute, USA
  • Hospital Clinico de Malaga, Spain
  • Renmin Hospital, Department of Cardiology, Wuhan University, China
  • Medical College of Georgia, Augusta University, Georgia, USA
  • National Medical Research Institute, Department of Medical Physics and Neuromagnetics, Boca Raton, Florida
  • Mississippi State University, USA
  • Ethical & Independent Review Services, MO, USA
  • University of Colorado's Institutional Review Board, USA
  • Hospital Costa Del Sol, Spain
  • University of Oklahoma Health Science Center, USA
  • Institute of Theoretical Physics and Advanced Studies for Biophysical Research, FL, USA
  • Weill Medical College of Cornell University, NY, USA
  • Hospital Serrania de Rhonda, Spain
  • Western Investigational Review Board, WA, USA

The resulting studies indicate the effects of non-ionizing pico-Tesla level electromagnetic fields on biological systems when applied to a diverse range of study areas including:

  • Healthy subjects
  • Ageing
  • Alzheimer's disease
  • Atrial fibrillation
  • Cancer cell studies
  • Cardiac rate and rhythm
  • Cell function
  • Chronic pain
  • Fibromyalgia
  • Mammary carcinoma
  • Motor neuropathy
  • Osteoarthritic knees
  • Parkinson’s disease
  • Radial and sciatic nerves
  • Telomeres
  • Thoracic spinal neurons
  • Type 2 diabetes
  • Wound healing


The Relaxation Response is an introduction to Magnetic Resonance Therapy by its founder Dr. Jerry Jacobson. It includes summaries of ten research studies conducted over two decades:

  1. Effect of Magnetic Fields on Excised Mice Sciatic Nerves In-Vitro
  2. Restoration of Nerve Ultrastructure and Recovery from Motorneuropathy in Mice by Electromagnetic Field
  3. Electromagnetic Fields Affect Cardiac Rate and Rhythm
  4. Efficacy and Safety of Low-Level Electromagnetic Field Treatment in Parkinson’s Disease.
  5. Effects of Low Intensity and Low Frequency Electromagnetic Field Stimulation (EMFS) on Thoracic Spinal Neurons Receiving Noxious Cardiac and Esophageal.
  6. Low Amplitude, Extremely Low Frequency Magnetic Fields for the Treatment of Osteoarthritic Knees.
  7. Effects of pico-Tesla electromagnetic field treatment on wound healing in rats.
  8. In-Vitro Cancer Cell Studies.
  9. Alleviation of Chronic Pain: Case-Controlled and Double-Blind Clinical Studies.
  10. Fibromyalgia: Double-Blind Placebo-Controlled Randomized Clinical Study.
Download E-Book

Clinical Study Summary

Cardiac Arrhythmias Study Sumnmary

2004
Clinical Study Summary

Wound Healing Study Summary

2003
Clinical Study Summary

Motor Neuron Study Summary

2003
Clinical Study Summary

Osteoarthritic Knee Study Summary

2000
Clinical Study Summary

Arthritic Knee Study Summary

1999
Clinical Study Summary

Atrial Fibrillation Study Summary

Nov 2019
Clinical Study Summary

Parkinson's Study Summary Poster

2009
Clinical Study Summary

Cardiac and Esophageal Pain Study Summary

2009

Osteoarthritic Knee Study Summary


Pico Tesla range magnetic fields tested in 4 site, 176 patient, double blind clinical study for treatment of Osteoarthritic Knees (2001)


J.I. Jacobson 1, R. Gorman 1, F. Chaviano 1, W.S. Yamanashi 2, I. Grinberg 3, M. Dayton 4, S. Haltiwanger 5, B. B. Saxena 6, B. Walters 7, L. Clayton 8, J. Lamberth 9

Arthritic Knee Study Summary: Clinical Efficacy of a Knee Three Compartment Arthritis Pain Palliative Treatment with Electromagnetic Fields (1999)


Dr. Pedro Alonso Atienza; Costa del Sol Hospital, Marbella, Spain

Dr. Joaquin Garcia Montes; Serrania Ronda Hospital, Spain


Parkinson’s Disease Study Poster: Efficacy and Safety of Low Level Electromagnetic Fields Treatment in Parkinson’s Disease.


Abstract: A Double-blind, Sham-stimulation Controlled Study of the Application of Magnetic Fields Using the Jacobson Resonator for the Treatment of Parkinson’s Disease (Poster 8)


O. Klepitskaya 1, R. Kumar 2 (2009)


1 University of Colorado Health Sciences Center, Department of Neurology, Aurora, CO, USA

2 Colorado Neurological Institute Movement Disorder Center, Englewood, CO, USA.


Magnetic Resonance: Impact on Cell Function


By Jerry Jacobson, PhD, DMD, IOM


Published in Dynamic Chiropractic – July 15, 2013, Vol. 31, Issue 14



Atrial Fibrillation Study Summary


Abstract: Low-Level Electromagnetic Fields Attenuate the Inducibility of Atrial Fibrillation


Daniel Sohinki, MD, MS 1, Stavros Stavrakis, MD, PhD 2, Sunny Po, MD, PhD 2, Julie A. Stoner, PhD 2, Benjamin J. Scherlag, PhD 2 1 Medical College of Georgia, Augusta University, Augusta, Georgia 2 University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (Nov 2019)


The Treatment of Cardiovascular Conditions – Letter From Heart Rhythm Institute, University of Oklahoma

Magnetic fields in noninvasive heart stimulation: A novel approach for anti-atrial fibrillation


Songyn Wang 1, Xiaoya Zhou 1, Zhuo Wang 1, Bing Huang 1, Liping Zhou 1, Mingxian Chen 2, Lilei Yu 1, Hing Jiang 1 1 Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei, China; 2 Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China


International Journal of Cardiology 190 (2015) 54-55




A quantum theory of disease, including cancer and the aging process


Jerry I Jacobson, Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, FL, USA (2016)


Analysis: Human Mammary Carcinoma (MCF-7/HTB-126) Cell Studies Suggest Possible Target-Specificity of Non-ionizing Magnetic Fields


Jerry I. Jacobson, Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, FL, USA (2016)



Analysis: Magnetic Resonance Targets Telomeres/Telomerase for Cancer Treatment?


Jacobson J I, Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, Florida, USA Published in Innovation Energy & Research 2016, 5:1


The use of low-level electromagnetic fields to suppress atrial fibrillation


Lilei Yu, MD 1, John W. Dyer, PhD 2, Benjamin J. Scherlag, PhD 2, Stavros Stavrakis, MD, PhD 2, Yong Sha, MD 2, Xia Sheng, MD 2, Paul Garabelli, MD 2, Jerry Jacobson, DMD, PhD 3, Sunny S. Po, MD, PhD 2 1 Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; 2 Heart Rhythm Institute and Department of Medicine, Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; 3 Pico-Telsa Therapies LLC, Littleton, Colorado (2015)




Telomeres; A dual resonance model for gerotargets and magnetic interaction energies


Jerry Jacobson 1, Benjamin Sherlag 2, 1. Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, Florida, USA; 2. Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA (2015)

Anti-aging Magnetic Resonance Therapy


By Jerry Jacobson, DMD, PhD, IOM Published in The American Chiropractor September 2015




Aging and magnetism: Presenting a possible new holistic paradigm for ameliorating the aging process and the effects thereof, through externally applied physiologic PicoTesla magnetic fields


Jerry Jacobson 1, Benjamin Sherlag 2


1 Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, FL, USA 2; Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA (2015)

Nerve Regeneration and Magnetic Resonance Energies


Jacobson J I, Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Jupiter, Florida, USA International Journal of Clinical & Medical Imaging, August, 2015




Cardiac and Esophageal Pain Study Summary


Effects on Rats of Low Intensity and Frequency Electromagnetic Field Stimulation on Thoracic Spinal Neurons Receiving Noxious Cardiac and Esophageal Inputs


Chao Qin, MD, PhD 1, J. Mark Evans, MD 1, William S. Yamanashi 2, PhD, Benjamin J. Scherlag, MD 2, Robert D. Foreman, PhD 1 Departments of 1 Physiology and 2 Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma


© 2005 International Neuromodulation Society

Cardiac Arrhythmias Study Summary


Magnetism and Cardiac Arrhythmias Study (2004)


Benjamin J. Scherlag 1, PhD, William S. Yamanashi 1, PhD, Yuemei Hou MD 2, PhD, Jerry I. Jacobson 3, PhD, Warren M. Jackman 1, MD, Ralph Lazzara, MD 1


1. Cardiac Arrhythmia Research Institute at the University of Oklahoma Medical Center, Oklahoma, USA

2. Xingjiang Medical University, Urumuqui, PR, China

3. Jacobson Resonance Enterprises, Boynton Beach, Florida



Wound Healing Study Summary


Effects of pico-tesla electromagnetic field treatment on wound healing in rats


C.Todd Trostel, DVM; Ron M. McLaughlin, DVM, DVSc; John G. Lamberth, PhD; Robert C. Cooper, DVM, MS; Steven H. Elder, PhD; Roy R. Pool, DVM, PhD; Cheng Gao, DDS, MS; Joseph A. Cromiak, PhD; Carolyn R. Boyle, PhD


From the Departments of Clinical Sciences (Trostel, McLaughlin, Cooper), Pathobiology and Population Medicine (Pool), and Basic Sciences (Gao, Boyle), College of Veterinary Medicine; the Department of Health, Physical Education, Recreation, and Sport (Lamberth, Cromiak), College of Education; and the Department of Agricultural and Biological Engineering (Elder), College of Agriculture and Life Sciences, Mississippi State University, Mississippi State, MS.


American Journal of Veterinary Research, Vol 64, No. 7, July 2003

Motor Neuron Study Summary


Mechanism of biological amplification in an experimental model utilizing picoTesla (PT) electromagnetic fields (2003)


Anjali Saxena,1 Jerry Jacobson,2 William Yamanashi,2 Benjamin Scherlag,3 John Lamberth,4 Brij Saxena 5


1. Department of Biological Sciences, Fairleigh Dickinson University, Teaneck, New Jersey, USA.

2. Institute of Theoretical Physics and Advanced Studies for Biophysical Research, Perspectivism Foundation, 2006 Mainsail Circle, Jupiter, Florida 33477, USA.

3. Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

4. Department of Recreation, Sports and Physical Therapy, Mississippi State University, Mississippi, USA.

5 Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, Weill Medical College of Cornell University, NY, USA.



Safety & Risk Studies



Five Institutional Review Boards (IRBs), including Independent Review Consulting, Inc. IRB, Western Investigational Review Board (WIRB), University of Colorado’s IRB (COMIRB), Ethical & Independent Review Services, and University of South Florida’s IRB have determined the predecessor to the PEMF Device, the Jacobson Resonator™, to be a non-significant risk (NSR) device when applied to the particular studies and protocols identified below. These protocols involved Parkinson Disease, Alzheimer Disease, Fibromyalgia, and Type 2 Diabetes patients for eight independent studies, as described below:


Efficacy of the application of magnetic fields to the treatment of Parkinson’s disease pilot study protocol, APPLIED MAGNETICS, LLC. Version 1.6, February 20, 2007. IRC study # 07021-02.


A double-blind, sham-stimulation controlled study of the application of magnetic fields using the Jacobson Resonator™ for the treatment of Parkinson’s disease: phase two pilot study protocol. Version 2.5, Oct 2007. IRC # 07102-01.


An open label extension study for subjects previously treated in either pilot I or pilot II studies of the application of magnetic fields using the Resonator™ for the treatment of Parkinson’s disease: Extension pilot study protocol, Version 4.0, March 14, 2008. IRC# 06052-01.IRC Resonator Device NSR #: DAM-003.


A controlled pilot study of the application of magnetic fields using the Resonator™ in adjunctive management of Type 2 Diabetes; Version 1.8, December 2, 2008; Pico-Tesla Magnetic Therapies, LLC., a subsidiary of APPLIED MAGNETICS, LLC. IRC # 08165-01


A randomized, double-blind, placebo-controlled study of the application of magnetic fields using the Resonator™ in adjunctive management of Type 2 Diabetes Mellitus, pilot study II. IRC # 09109-01


A multiple site, randomized, double-blind, sham-stimulation controlled study of the application of magnetic fields using the Resonator™ device for the treatment of Parkinson’s disease; Pico-Tesla Magnetic Therapies, LLC. April 7, 2010. IRC # 09026:


A single site, randomized, single-blind, placebo-controlled study to evaluate the safety and efficacy of the application of magnetic fields using the Resonator for the treatment of Alzheimer’s Disease in addition to standard of care, Pico-Tesla Magnetic Therapies, LLC. October 12, 2010. USF IRB Study # Pro00001676


A randomized, double-blind, placebo-controlled, evaluation of the application of magnetic fields using the Resonator™ device for the treatment of fibromyalgia: pilot study protocol. Pico-Tesla Magnetic Therapies, LLC. November 2, 2010, E&I Review Services Study # 10242-01


Clinical Research Disclaimer



All research and clinical material is for informational purposes only. Readers are encouraged to confirm the information contained herein with other sources. The information is not intended to replace medical advice offered by physicians.